P\u00e2n\u0103 la 88% dintre \u0219oarecii vaccina\u021bi au r\u0103mas f\u0103r\u0103 tumori, \u00een func\u021bie de tipul de cancer testat, demonstr\u00e2nd un poten\u021bial uria\u0219 pentru imunoterapie preventiv\u0103. Aceast\u0103 tehnologie activeaz\u0103 o memorie imunitar\u0103 sistemic\u0103, preg\u0103tind sistemul imunitar s\u0103 recunoasc\u0103 \u0219i s\u0103 distrug\u0103 celulele canceroase \u00eenainte ca acestea s\u0103 se dezvolte.\u200b<\/p>\n
\u00cen teste cu antigene specifice melanomului, 80% dintre \u0219oarecii vaccina\u021bi au supravie\u021buit peste 250 de zile f\u0103r\u0103 tumori, spre deosebire de cei din grupurile de control, care au murit \u00een maximum 35 de zile.<\/p>\n
Utiliz\u00e2nd lizat tumoral de la celule canceroase reale, vaccinul a ob\u021binut rate de respingere tumoral\u0103 de 88% pentru cancerul pancreatic, 75% pentru cancerul mamar triplu negativ \u0219i 69% pentru melanom, bloc\u00e2nd complet metastazele pulmonare. Prabhani Atukorale, profesor asistent de inginerie biomedical\u0103 \u0219i autor principal, subliniaz\u0103 c\u0103 metastazele r\u0103m\u00e2n principala cauz\u0103 de mortalitate \u00een cancerele agresive precum melanomul sau pancreaticul.\u200b<\/p>\n
Nanoparticulele lipidice ac\u021bioneaz\u0103 ca un \u201esuperadjuvant\u201d, combin\u00e2nd antigene canceroase cu stimuli multipli pentru a imita alertele naturale ale agen\u021bilor patogeni, gener\u00e2nd un r\u0103spuns intens al celulelor T.<\/p>\n
Aceast\u0103 structur\u0103 stabilizeaz\u0103 ingredientele imune care altfel nu se combin\u0103 bine, cre\u00e2nd o activare imunitar\u0103 puternic\u0103 \u0219i memorie de lung\u0103 durat\u0103 \u00een \u00eentregul organism. Griffin Kane, cercet\u0103tor postdoctoral \u0219i coautor, eviden\u021biaz\u0103 rolul esen\u021bial al celulelor T specifice tumorii \u00een supravie\u021buirea remarcabil\u0103 observat\u0103.\u200b<\/p>\n
Platforma este flexibil\u0103, put\u00e2nd fi adaptat\u0103 la diverse tipuri de cancer, at\u00e2t pentru tratament, c\u00e2t \u0219i pentru preven\u021bie la persoane cu risc ridicat. Descoperirea a dus la fondarea NanoVax Therapeutics de c\u0103tre Atukorale \u0219i Kane, cu scopul de a traduce tehnologia \u00een terapii clinice pentru pacien\u021bi.<\/p>\n
De\u0219i testele sunt preliminare pe \u0219oareci, rezultatele deschid drumul spre vaccinuri anti-cancer personalizate, transform\u00e2nd abordarea global\u0103 a oncologiei.<\/p>","protected":false},"excerpt":{"rendered":"
P\u00e2n\u0103 la 88% dintre \u0219oarecii vaccina\u021bi au r\u0103mas f\u0103r\u0103 tumori, \u00een func\u021bie de tipul de…<\/p>\n","protected":false},"author":0,"featured_media":50049,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-50048","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actual"],"_links":{"self":[{"href":"https:\/\/247stiri.ro\/index.php\/wp-json\/wp\/v2\/posts\/50048","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/247stiri.ro\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/247stiri.ro\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/247stiri.ro\/index.php\/wp-json\/wp\/v2\/comments?post=50048"}],"version-history":[{"count":0,"href":"https:\/\/247stiri.ro\/index.php\/wp-json\/wp\/v2\/posts\/50048\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/247stiri.ro\/index.php\/wp-json\/wp\/v2\/media\/50049"}],"wp:attachment":[{"href":"https:\/\/247stiri.ro\/index.php\/wp-json\/wp\/v2\/media?parent=50048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/247stiri.ro\/index.php\/wp-json\/wp\/v2\/categories?post=50048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/247stiri.ro\/index.php\/wp-json\/wp\/v2\/tags?post=50048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}